لم يتم دراسة هذا الاستخدام في المرضى الذين يعانون من ضعف كبير في وظائف الكبد.
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يمنع استخدام دواء سيلدينافيل دون استشارة الطبيب المختص في الحالات الآتية:
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وجود عوامل تزيد من خطر الإصابة بالانتصاب المستمر، مثل فقر الدم المنجلي، الورم النخاعي المتعدد، وسرطان الدم.